Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus HIV. VIAGRA was administered to more than 3, patients aged 19 to 87 years, with ED of various etiologies organic, psychogenic, mixed with a mean duration of 5 years. Mean sildenafil plasma concentrations measured after the administration of a single oral dose of mg to healthy male volunteers is depicted below: Figure 5: Mean Sildenafil Plasma Concentrations in Healthy Male Volunteers. In vivo studies: No significant interactions were shown with tolbutamide mg or warfarin 40 mg , both of which are metabolized by CYP2C9. Sexual activity may be a strain on your heart, especially if you have heart disease. Tell your doctor if any of these symptoms are severe or do not go away: headache. Tell your doctor or pharmacist if you are taking nitrates medications for chest pain such as isosorbide dinitrate Isordil , isosorbide mononitrate Monoket , and nitroglycerin Nitromist, Nitro-Dur, Nitrostat.Headache, flushing, and upset stomach are common Viagra side effects. These effects are usually mild and often resolve on their own. While rare, Viagra can cause an erection that lasts longer than 4 hours (priapism). This can result in permanent damage if left untreated. Vision changes are also possible. Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise in adults (Liqrev, Revatio) and children 1 year of age and older (Revatio) with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the . Rarely reported side effects include: an erection that will not go away (priapism). If you have an erection that lasts more than 4 hours, get medical help right away. If it is not treated right away, priapism can permanently damage your penis. sudden vision loss in one or both eyes.