Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. Debunking the Myths Over time, testosterone has gained quite a reputation for being linked with aggression and anger. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. Sildenafil usually should not be taken more than once every 24 hours. Ans : Yes, it can be taken with paracetamol. · Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension. Includes sildenafil side effects, interactions and indications. Virtual Care Don’t want to leave the house? Connect with a licensed provider 7 days a week from the comfort of home. Explore Virtual Care Loading MinuteClinic can treat over . Get drug information Search for a drug by name or NDC number and get complete drug information. It’s like the printout attached to your refill—only electronic. Help me find my .