When oral medications might not be safe Check with your health care team before you take any medicine for erectile dysfunction. It is important to consult with healthcare professionals to ensure the samples are obtained from reputable sources and to receive proper guidance on their use. They have the same benefits and risks as their brand-name counterparts. Comparing prices across different pharmacies and online platforms can help identify the best deals. People with heart conditions should never take ED medications without consulting a doctor. Minimal side effects: Avanafil has been reported to have a lower incidence of side effects than other PDE5 inhibitors.Top 5 ED Pills That Are Like Viagra. Performer 8 – Overall Best Over The Counter ED Pills; Top Selling. VigRX Plus – Best Male Enhancement Pills For Better Sex Drive. TestoPrime – Best Sex Pills. The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. Generic Viagra (sildenafil) is available as a , , , and milligram (mg) pill and in liquid form. It’s meant to be taken as needed — about an hour before sex — but shouldn’t be.