This increased blood flow can cause an erection. Vardenafil also does not have an effect on PDE6, which means that it does not have vision adverse effects. Vardenafil can be taken with or without food. Your doctor will probably start you on an average dose of vardenafil tablets and increase or decrease your dose depending on your response to the medication. These include a heart attack, stroke or a serious heart rhythm disorder in the past six months. It might work longer if you have mild to moderate erectile dysfunction.Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. This boosts blood flow and helps you get an erection from sexual activity. How oral medicines differ Each oral medicine for ED has a slightly different chemical makeup. What is vardenafil? Vardenafil is used in adult men to treat erectile dysfunction (impotence). Vardenafil may also be used for purposes not listed in this medication guide. Vardenafil side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, vardenafil works by increasing blood flow to the penis.