Drink a full glass of water at the same time as you take a tablet. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. It is rapidly absorbed and eliminated, resulting in minimal accumulation, and has dose-proportional pharmacokinetics which are unaffected by multiple dosing. The recommended starting dose is 30 mg administered with water as needed, 1—3 hours prior to sexual intercourse with a maximum dosing frequency of once every 24 hours. Interpersonal difficulty related to ejaculation Changes from baseline in interpersonal difficulty related to ejaculation following dapoxetine therapy were reported in five studies Table 3. The two integrated analyses reporting this outcome found significantly better CGI scores compared with placebo at study endpoint. Do not take more than one tablet in any 24 hours.Dapoxetine significantly decreased the AUC of PCA-induced intraseminal vesicle pressure increases and bulbospongiosus muscle contractile bursts by 78% at all doses, by 91% . Dapoxetine is indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have all of the following: persistent or recurrent ejaculation with . rows · DrugBank Accession Number. DB Background. Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II .

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