This medicine works best when you take it on an empty stomach an hour before sex. These medicines all work well for ED. This question arises because we are well aware of the crucial role that testosterone plays in muscle building and Does Testosterone Make You Angry? You can take this medicine with or without food 30 minutes before sex, depending on the dose. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. This particular component of testosterone plays a vital role in our overall health and Does Semen Retention Increase Testosterone?The Savings Offer and Program expire on 12/31/ For further information, call , visit , or write: Viatris Inc., P.O. Box , Mission, KS . To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Take sildenafil at least 30 minutes, but no more than 4 hours, before sexual . Refill and transfer prescriptions online or find a CVS Pharmacy near you. Shop online, see ExtraCare deals, find MinuteClinic locations and more.