Tadalafil is its active ingredient and is available as a generic drug. While each PDE5 inhibitor differs slightly, they’re very similar in treating erectile dysfunction. Finding an online ED provider can feel overwhelming. In trials of the drug, individuals taking Cialis saw a significant reduction in the frequency and urgency of urination and improved urine flow. Psychological factors like stress, depression, or anxiety can also contribute.Save with GoodRx. GoodRx can help you save over 80% off the average retail price of the generic versions. Generic sildenafil at certain pharmacies is as low as $ with a free GoodRx discount. You can also find generic tadalafil and vardenafil for as low as $ and $ , respectively. How Cialis Works. Tadalafil and other PDE5 inhibitors primarily work by inducing muscle relaxation. Tadalafil stops the breakdown of a chemical responsible for relaxing muscles. In ED and PAH, the drug targets muscle cells in blood vessels. When the blood vessel muscle cells relax, this expands the vessel and increases blood flow; this .  · Below, we’ll detail nine of the most common tadalafil interactions to keep in mind. 1. Nitrates. Nitrates are used to treat and prevent angina (chest pain) caused by heart disease. Examples include nitroglycerin (Nitrostat), isosorbide mononitrate (Monoket), and isosorbide dinitrate (Isordil).

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