Objectives: Explain the mechanism of action of sildenafil in the treatment of erectile dysfunction and pulmonary arterial hypertension. Box , Mission, KS If your pharmacy does not participate, you may be able to submit a request for a rebate in connection with this Savings Offer. Many people have no side effects or only mild ones. Place the tip of the syringe into you or your child’s mouth and point it towards the cheek. May make this condition worse. It is in the phosphodiesterase-5 inhibitor PDE5-I class of medications. · The effects may be increased because of slower removal of the medicine from the body. Leukemia (blood related cancer) or. Multiple myeloma (blood related cancer) or. Sickle-cell anemia (blood disorder)—Sildenafil should be used with caution in these patients as problems with prolonged erection of the penis may occur. Sildenafil is available as oral tablets of 25 mg, 50 mg, and mg strength for erectile dysfunction (ED). Most patients receive a prescription for 50 mg of oral sildenafil, taken as needed approximately 1 hour before sexual activity. The dose can be titrated upward to a maximum of mg or down to 25 mg based on individual . Sildenafil is a medicine used to treat erection problems (erectile dysfunction). Sildenafil is also sometimes used to treat pulmonary hypertension (high blood pressure in the blood vessels that supply the lungs). If you have erection problems sildenafil works by temporarily increasing blood flow to your penis when you get sexually excited.