All three of the RCTs in Table 2 reporting changes in personal distress related to ejaculation found significant improvements with dapoxetine therapy from baseline compared with placebo at end-of-study. Have you had problems with premature ejaculation before? Comparison of the safety and efficacy of the on-demand use of sertraline, dapoxetine, and daily use of sertraline in the treatment of patients with lifelong premature ejaculation: A prospective randomised study. Your provider might also do a physical exam. This may allow you to delay ejaculation when you have sex with your partner.Dapoxetine tablets. Dapoxetine is prescribed for the treatment of premature ejaculation. Take one tablet hours before you have sex. The most common side-effects include . Dapoxetine {(+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride, Janssen Cilag (Johnson and Johnson, New Jersey USA)} is the first . Dapoxetine is being developed by J&J’s drug delivery subsidiary Alza and Pharmaceutical Product Development. If approved by the FDA, it will be marketed in the USA by J&J’s .