Neuroreport ; Am J Psychiatry ; Eur Urol ; Effects of a new functional-sexological treatment for premature ejaculation. All three of the RCTs in Table 2 reporting changes in personal distress related to ejaculation found significant improvements with dapoxetine therapy from baseline compared with placebo at end-of-study. How to store dapoxetine Keep all medicines out of the reach and sight of children.1 day ago · PRILIGY ® WARNING: PRILIGY can make you faint. You may experience warning symptoms such as nausea, dizziness or light-headedness before you faint. Immediately lie down or sit down with your head.  · Modi NB, Dresser MJ, Simon M, et al. Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation. J Clin Pharmacol ; [Google Scholar]. Dapoxetine {(+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride, Janssen Cilag (Johnson and Johnson, New Jersey USA)} is the first compound specifically developed for the treatment of PE. Dapoxetine is a potent SSRI (pKi = 8 nM), structurally similar to fluoxetine (Figure 1) [Sorbera et al. ].