Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The view that some men have a genetic predisposition to lifelong PE is supported by animal studies showing a subgroup of persistent rapidly ejaculating Wistar rats, 6 an increased familial occurrence of lifelong PE, 5 a moderate genetic influence on PE in the Finnish twin study, 21 and the recent report that genetic polymorphism of the 5-HT transporter gene determines the regulation of IELT. Although the information stored on FDB Multilex is updated on a regular basis, healthcare professionals should ensure that they are satisfied that the information they have is current. This is an open access article. It can also increase the risk of fainting. Keywords: premature ejaculation, selective serotonin re-uptake inhibitors SSRIs , dapoxetine, intravaginal ejaculatory latency time IELT Introduction Over the past 20—30 years, the premature ejaculation PE treatment paradigm, previously limited to behavioural psychotherapy, has expanded to include drug treatment. · Dapoxetine 30 mg Dapoxetine 60 mg; C max (ng/ml) T max (hr) Initial T 1/2 (hr) Terminal T 1/2 (hr) Effect of high fat meal: C max (fasted) – C max (high fat meal) – T max (hr) (fasted) – T max (hr) (high fat meal) – The maximum dose of dapoxetine should be 30 mg if dapoxetine is combined with any of these drugs (see sections , and below). These two measures apply to all patients unless the patient has been verified to be a CYP2D6 extensive metabolizer by geno- .  · DAPOX 30 MG TABLET is used in the treatment of Premature ejaculation. View DAPOX 30 MG TABLET (strip of 6 tablets) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on