It lasts 4 to 5 hours, or longer if you have mild to moderate ED. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. These medicines are called PDE5 inhibitors. Do not take a double dose to make up for a missed one. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Other uses for this medicine This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly.Sildenafil (Viagra). This medicine works best when you take it on an empty stomach an hour before sex. The body takes longer to absorb it after a high-fat meal or . Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual . What is sildenafil? Sildenafil is a prescription drug. It comes in the form of a tablet and suspension (liquid). Both are taken by mouth. It also comes in an .

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