If you do drink grapefruit juice, do not take a dapoxetine tablet for at least 24 hours afterwards. If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work. The dose may be increased to 60 mg the maximum recommended dose based on efficacy and tolerability. Do not take more than one tablet in any 24 hours. Important information about all medicines Never take more than the prescribed dose.Dapoxetine 30–60 mg administrated orally is currently the most recommended drug and should be taken 1–2 h before sexual intercourse (McMahon et al., ). However, the effect of these medications on premature ejaculation associated with PD has not been systematically evaluated (Bronner et al., ). Kilinc et al reported that moderate physical activity longer than 30 min at least 5 times a week leads to ejaculation delay in patients with premature ejaculation. In their study, 35 patients were treated with dapoxetine, 30 mg on demand; 35 performed moderate physical activities; and 35 performed minimal physical activity. The most common treatment-related adverse effects included nausea (% for 30 mg, % for 60 mg), dizziness (% for 30 mg, % for 60 mg), and headache (% for 30 mg, % for 60 mg), and evaluation of validated rated scales demonstrated no SSRI class-related effects with dapoxetine use.